Research Topics

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Research Topics

Research Topics 01
Multiplex Immunoblot technology
Multiplex immunoblot technology is a method for simultaneously detecting multiple proteins or biomarkers in a single assay. This technology builds on traditional western blotting but allows for the analysis of multiple targets at once, enabling comprehensive profiling. It is particularly suitable for diagnostics where sample quantity is limited, as it can analyze multiple targets from a single sample. Throughput and time efficiency are significantly increased by enabling the detection of multiple targets in a single test.
Research Topics 02
Magnetic particle based
chemiluminescent immunoassay
A chemiluminescent immunoassay (CLIA) is a biochemical technique used to detect specific molecules (such as proteins and hormones) in a sample. It combines the immunoassay principle of specific binding between an antigen and an antibody with chemiluminescence, which generates light through a chemical reaction. CLIA has high sensitivity, is capable of detecting very low concentrations of antigens, and provides accuracy and reproducibility, ensuring consistent results for the same sample. Additionally, it has a wide dynamic range, allowing the measurement of a broad range of antigen concentrations without the need for dilution, making it suitable for handling a variety of samples.
Research Topics 03
Cell-mediated immunity technology
IInterferon Gamma Release Assay (IGRA) is a technique used to determine infection status by measuring the body's immune response. This technology is based on the principle that T cells release interferon-γ in response to specific antigens. This technique minimizes non-specific reactions and reduces the influence of other infections or vaccinations by measuring the immune response to a particular pathogen. It is useful for diagnosing various infectious diseases that require high specificity and sensitivity.
Research Topics 04
Highly sensitive real-time PCR technology
The polymerase chain reaction (PCR) technology is an exceptionally sensitive molecular biological detection method, capable of detecting and quantifying nucleic acids at very low concentrations. During the PCR cycling process, DNA is first separated into single strands, after which primers and probes bind to the target DNA. Subsequently, DNA polymerase synthesizes a new DNA strand along the primer. The fluorescent probe used in this process increases the fluorescence signal as the fluorescent reporter moves away from the quenching material in the presence of the target material. The amplification of the target material through PCR cycling, combined with the highly sensitive fluorescence signal, ensures superior sensitivity and reproducibility. Invitros has advanced PCR technology to achieve sensitivity that can detect up to a single molecular level and specificity that can distinguish up to a single nucleotide sequence difference. This technology significantly contributes to human health by rapidly and accurately detecting infectious agents and diseases caused by genetic mutations.
Research Topics 05
High quality nucleic acid extraction 
Invitros' high-purity and high-efficiency nucleic acid extraction technology is based on SPRI (Solid Phase Reversible Immobilization) beads. This method utilizes magnetic-responsive beads to rapidly and efficiently purify nucleic acids such as DNA and RNA. It isolates nucleic acids through a series of processes including cell lysis, bead binding, washing, and elution from a variety of human-derived samples such as whole blood, plasma, feces, urine, respiratory swabs, vaginal swabs, sputum, and culture medium. The technology stands out for its high efficiency, superior quality, potential for automation, simplicity, high reproducibility, and broad applicability. The extracted high-quality nucleic acids are suitable for a wide range of molecular biology applications, including qPCR, Microassay, ddPCR, and sequencing analysis.
Research Topics 06
Reverse Blot Hybridization Assay
The Reverse Blot Hybridization Assay technology, integrated into Invitros' Line Blot assay products, is a sophisticated molecular biology technique designed for the rapid and precise detection of specific DNA or RNA sequences. This method excels in the swift diagnosis of pathogens and the analysis of genetic mutations. It involves the detection of PCR-amplified DNA products by binding specific oligonucleotides to targeted gene sequences immobilized on a membrane. The presence of these sequences is then visually confirmed through a color development reaction. Notably, this technology can simultaneously detect approximately 20 to 30 different pathogens or genetic mutations, significantly accelerating diagnostic processes.
Research Topics 07
Novel direct PCR technology
Invitros' unique direct PCR method is a technology patented both domestically and internationally. It achieves the same level of sensitivity as traditional real-time PCR while incorporating a simplified purification process. Unlike conventional PCR detection methods, this technique uses samples directly as RT-PCR templates without nucleic acid separation and purification. This simplification not only shortens preparation time but also minimizes cross-contamination and sample loss, eliminating the need for expensive DNA extraction kits or enzymes. The COVID-19 diagnostic reagents utilizing this technology have proven crucial in effectively curbing the spread of the disease during the pandemic, enabling early identification of infected individuals and facilitating appropriate medical interventions.